When asked if Isabelle is aware of what happened in the first four Transformers movies, Moner revealed a connection between the character, Sqweeks and the “Battle of Chicago” from Transformers: Dark of the Moon:
She was actually involved in the battle of Chicago, her family. From that stems dark memories and the reason why she’s been living there and then joins [Cade].
Moner also confirmed that Izabella has befriended the Sqweeks character before she and Cade meet in The Last Knight:
Yeah, he’s like my lifelong friend ever since the battle of Chicago. He got a little bit messed up so he can’t transform fully. So he’s getting there; I’m trying to fix him. My character is also a welder. She fixes things. She’s known for fixing things. And she knows a lot about Transformers because she’s lived with them after she lost her family in the battle of Chicago.